ABOUT THE MEETING
We are pleased to announce the BeSHG/NVHG annual genetics symposium, to be held on 21st and 22nd April 2022 at the Bruges Meeting & Convention Centre (BMCC). This 2-day symposium will be preceded on 20th April 2022 by the Genetics Retreat (previously known as the Rolduc meeting). The 2022 genetics symposium will be organized jointly by the Belgian Society for Human Genetics (BeSHG) and the Dutch Society for Human Genetics (NVHG). We hereby continue a tradition we started in 2016 to have a joint meeting every 3 years. As usual, the NVHG symposium is organized in collaboration with the VKGL, VKGN and NACGG. Please note that neither BeSHG nor NVHG nor Genetics Retreat will organize a separate meeting in 2022. Theme Young researchers Venue Staying overnight in Bruges Abstracts Follow the BeSHG website for the most actual information on the symposium. The final program of the meeting will become available towards the end of March. We hope to meet you all at the 2022 BeSHG and NVHG symposium and Genetics Retreat in April in Bruges. Feel free to forward this mailing to your colleagues. On behalf of the Executive Committees, |
| Local organizing team UZA/UA Centre of Medical Genetics Antwerp E: arvid.suls@uantwerpen.be T: +32 (0) 3 275 9763 |
ABOUT THE MEETING
NVHG Annual Meeting 2023
As every year, the NVHG organizes a conference for all Dutch geneticists to connect, share knowledge, collaborate, and network. The NVHG aims to provide the latest genetics and genomics advancements, from basic to translational research from within and outside of the Netherlands.
The 2023 NVHG Annual Meeting took place on 20th and 21st of April 2023 in Koningshof, Veldhoven. The word cloud that was created by the participants provides an impression of that meeting.
WELCOME
Welcome to the annual meeting of the Dutch society of Human Genetics. It is a pleasure to welcome you in again Veldhoven. For the first time in three years’ time a “live-only” meeting. Back to the old pre-COVID times!
The NVHG organizes this unique yearly conference for all Dutch geneticists to connect, share knowledge, collaborate, and network. We aim to provide the latest genetics and genomics advancements, from basic to translational research.
This years’ scientific program will focus on diversity in genetics, therapy development, newborn- and population screenings options and technological developments. These topics will be addressed during presentations and panel discussions throughout the conference.
We have invited plenary speakers Charles Agyemang, Bart Ferwerda and Veronika Lipphardt, who will share their knowledge and experiences in studying Diversity in Genetics. Our keynote speaker Dr. Benjamin Peter will give us some insight in the world of archeogenetics with a presentation on The Neanderthal family project.
The second day will start with HUGE nl, a national platform for all stakeholders in genetics, to jointly discuss and formulate how to best approach and apply the newest genetic knowledge and possibilities in society.
We have invited excellent plenary speakers to enlighten us with recent innovations in genomics; Alexander Hoischen, Jeroen de Ridder, Bas Heijmans and Jesse Swen, will provide an update on optical genome mapping, nanopore sequencing, epigenetic profiling and “genetics informed drug treatment”.
Finally, we are proud to announce that Prof. dr. Christian Gilissen, has been selected as the recipient of the NVHG ‘Lodewijk Sandkuijl Lecture 2023’.
This meeting would not have been possible without the generous support from our sponsors, the Simons Fonds as well as bioscience companies. We thank all of them and encourage all participants to see the representatives at the stands to take note of the products offered by them.
I wish you an inspiring meeting and a great time interacting with your colleagues on stage and/or on the dancefloor!
LODEWIJK SANDKUIJL
DR. MICHEL NIVARD
The winner of the Lodewijk Sandkuijl award 2021 is Dr. Michel Nivard, VU University Amsterdam. He will receive this prize during the NVHG Annual Meeting on Friday 17 September, and will give an overview of the research he is conducting. Interested? Register now for the NVHG Annual Meeting 2021.
GALJAARD LECTURE
PROF. CISCA WIJMENGA
The NVHG board is proud to announce that the biannual Galjaard lifetime achievement award 2022 is awarded to prof. dr. Cisca Wijmenga for her international leadership in the field of human genetics. Prof. dr. Wijmenga will give her award lecture at the BeSHG/NVHG joint symposium on 21 April in Bruges, Belgium.
SPEAKERS
PROGRAM
*This is preliminary program (version 16 of April 2023)
Time | Thursday 20th April |
09:00 | Registration |
R: Holland Foyer | |
09:45 | Opening by Prof. Dr. Mieke van Haelst (President NVHG) |
R: Auditorium | |
10:00 | Plenary session 1 |
R: Auditorium Chairs: André Uitterlinden & Gijs Santen (NVHG) | |
10:00 | Prof. Dr. Charles Agyemang (Amsterdam) |
Ethnic inequalities in health in Europe: Current & Future perspectives | |
10:30 | Dr. Bart Ferwerda (Amsterdam) |
HELIUS – a genetic map of a modern urban society | |
11:00 | Prof. Dr. Veronika Lipphardt (Freiburg) |
Genetic research in underrepresented population | |
11:30 | Prof. Dr. Mieke van Haelst (NVHG) |
Clinical genetic experiences in a Caribbean setting | |
12:00 | Plenary session 2 |
R: Auditorium Chair: Lude Franke (NVHG) | |
12:00 | Prof. Dr. Jesse Swen (Leiden) |
Genetics informed drug treatment: from promise to practice | |
12:30 | Lunch: Holland Foyer & room 65 |
13:30 | Parallel session 1 A/B/C Co-organized with VKGL, VKGN, NACGG |
13:30 | 1A: Diversity in Genetic Studies – a debate |
R: Auditorium Chairs: Boy Vijlbrief (Rotterdam) & Sam Riedijk (Rotterdam) | |
13:30 | 1B: Lifelong Screening |
R: Parkzaal Chairs Erik Sistermans (Amsterdam) & Marielle van Gijn (Groningen) | |
13:30 | Sander Stegmann (Maastricht) |
Use of WES analysis for preconceptional screening, the Maastricht experience | |
13:50 | Jasper Linthorst (Amsterdam) |
Improving prenatal screening by NIPT datamining | |
14:10 | Gea Kiewiet PhD (Groningen) |
Towards NGS-based newborn screening: a study to prepare for challenges ahead | |
14:30 | Nienke van der Stoep (Leiden) |
Can PRS for melanoma be used for population screening? | |
13:30 | 1C: My Profiled Genome (pre-registered session) |
| R: room 82 Chair: Johan den Dunnen (NVHG) |
15:00 | Parallel session 2 A/B |
15:00 | Parallel session 2A |
R: Auditorium Chair: Gijs Santen (NVHG) | |
15:00 | Marieke Klein (Nijmegen) |
| Interactions of rare copy number variations with polygenic risk scores in psychiatric disorders and quantitative traits |
15:20 | Janita Bralten (Nijmegen) |
Shared underlying genetic architecture of psychiatric symptoms with hematological traits | |
15:40 | Eline van der Sluijs (Leiden) |
Effect of clonazepam in patients with ARID1B-related intellectual disability | |
16:00 | Lex Dingemans (Nijmegen) |
PhenomAD-NDD: the Phenomics Aggregation Database of comorbidities in 42,411 pediatric individuals with Neuro Development Disorders | |
15:00 | Parallel session 2B |
R: Parkzaal Chair: Roland Kuiper (NVHG) | |
15:00 | Naijm Lahrouchi (Amsterdam) |
Loss-of function variance POPDC2 cause a novel autosomal recessive syndrome with sinus node disease and AV conduction defects in combination with hypertrophic cardiomyopathy | |
15:20 | Gaby Schobers (Nijmegen) |
Finally finding the second variant in recessive disorders by genome sequencing | |
15:40 | Maayke de Koning (Leiden) |
Biallellic variants in SNAPIN are associated with a novel foetal neuroanatomical phenotype | |
16:00 | Robin Wijngaard (Nijmegen) |
Analysis of mobile elements in + 60,000 exome sequencing samples identifies pathogenic variants in 3 per 10,000 patients | |
16:20 | Posters presentation with coffee & tea: Holland Foyer & Room 65 |
17:30 | Keynote lecture by Dr. Benjamin Peter (Leipzig) |
The Neanderthal family project | |
R: Auditorium Chair: Roland Kuiper (NVHG) | |
18:30 | Social evening program: Brabantzaal |
18:30 | Pre-dinner drinks |
19:00 | Dinner |
21:00 | Network event |
Time | Friday 21st April |
08:30 | Registration |
R: Holland Foyer | |
09:00 | Plenary session 3: HUGE NL |
Chair: Johan den Dunnen, Lude Franke, Mieke van Haelst & Terry Vrijenhoek (NVHG) | |
The national think tank for Human Genetics in the Netherlands | |
10:10 | Coffee break: Holland Foyer |
10:30 | Parallel sessions 3: A/B |
10:30 | Parallel session 3A |
R: Auditorium Chair: Lisenka Vissers (NVHG) | |
10:30 | Dilys Weijers (Utrecht) |
Molecular analysis of cancer genomes in children with Lynch syndrome: exploring causal associations | |
10:50 | Snežana Hinić (Nijmegen) |
Biallelic germline pathogenic variants in CHEK2 predispose to multiple primary malignancies in the absence of homologous recombination deficiency | |
11:10 | Lore van Riel (Amsterdam) |
Prevalence of pathogenic FLCN variants | |
11:30 | Richarda de Voer (Nijmegen) |
Microsatellite instability in non-colorectal and non-endometrial malignancies in patients with Lynch syndrome | |
10:30 | Parallel session 3B |
Chair: Lude Franke (NVHG) | |
10:30 | Marlen Lauffer (Leiden) |
Patient and variant stratification for personalized genetic treatments of nano‐rare diseases | |
10:50 | Rick Essers (Maastricht) |
The nature and prevalence of chromosomal dynamics in first trimester spontaneous pregnancy loss | |
11:10 | Wouter Steyaert (Nijmegen) |
Systematic Pan-European reanalysis of 6,004 genetically undiagnosed rare disease families yields 506 new diagnoses | |
11:30 | Peter Taschner (Leiden) |
Check the test: how to assess the quality of Direct‐to‐Consumer genetic tests? | |
12:00 | Lunch and poster viewing: Holland Foyer & room 65 |
12:30 | NVHG General Assembly |
Room: Auditorium | |
13:15 | Plenary session 4: Innovations in Genomics |
R: Auditorium Chairs: Lisenka Vissers (NVHG) & Masoud Zamani Esteki (Maastricht) | |
Dr. Alexander Hoischen (Nijmegen) | |
Optical genome mapping: Hidden SVs in rare diseases | |
Dr. Ir. Jeroen de Ridder (Utrecht) | |
Ultra-fast deep-learned pediatric CNS tumor classification during surgery | |
Prof. Dr. Bas Heijmans (Leiden) | |
Genetics: a gateway to understanding epigenetics | |
15:10 | Emotional genetics: Auditorium |
15:30 | NVHG award ceremony |
R: Auditorium Chair: Mieke van Haelst (NVHG) | |
Lodewijk Sandkuijl Award lecture 2023 | |
NVHG Young Investigator Award, Annual Award, Poster Award | |
16:15 | Closing remarks |
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| Time | Thursday 20th April |
| ||
| 09:00 | Registration |
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| |
|
| R: Holland Foyer |
|
| |
| 09:45 | Opening by Prof. Dr. Mieke van Haelst (President NVHG) |
| ||
|
| R: Auditorium |
|
| |
| 10:00 | Plenary session 1 |
|
| |
|
| R: Auditorium Chairs: André Uitterlinden & Gijs Santen (NVHG) |
| ||
|
| 10:00 | Prof. Dr. Charles Agyemang (Amsterdam) |
| |
|
|
| Ethnic inequalities in health in Europe: Current & Future perspectives |
| |
|
| 10:30 | Dr. Bart Ferwerda (Amsterdam) |
| |
|
|
| HELIUS – a genetic map of a modern urban society |
| |
|
| 11:00 | Prof. Dr. Veronika Lipphardt (Freiburg) |
| |
|
|
| Genetic research in underrepresented population |
| |
|
| 11:30 | Prof. Dr. Mieke van Haelst (NVHG) |
| |
|
|
| Clinical genetic experiences in a Caribbean setting |
| |
| 12:00 | Plenary session 2 |
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| |
|
| R: Auditorium Chair: Lude Franke (NVHG) |
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|
| 12:00 | Prof. Dr. Jesse Swen (Leiden) |
| |
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|
| Genetics informed drug treatment: from promise to practice |
| |
| 12:30 | Lunch: Holland Foyer & room 65 |
| ||
|
|
|
|
|
|
| 13:30 | Parallel session 1 A/B/C Co-organized with VKGL, VKGN, NACGG |
| ||
|
| 13:30 | 1A: Diversity in Genetic Studies – a debate |
| |
|
|
| R: Auditorium Chairs: Boy Vijlbrief (Rotterdam) & Sam Riedijk (Rotterdam) |
| |
|
| 13:30 | 1B: Lifelong Screening |
| |
|
|
| R: Parkzaal Chairs Erik Sistermans (Amsterdam) & Marielle van Gijn (Groningen) |
| |
|
|
| 13:30 | Sander Stegmann (Maastricht) |
|
|
|
|
| Use of WES analysis for preconceptional screening, the Maastricht experience |
|
|
|
| 13:50 | Jasper Linthorst (Amsterdam) |
|
|
|
|
| Improving prenatal screening by NIPT datamining |
|
|
|
| 14:10 | Gea Kiewiet PhD (Groningen) |
|
|
|
|
| Towards NGS-based newborn screening: a study to prepare for challenges ahead |
|
|
|
| 14:30 | Nienke van der Stoep (Leiden) |
|
|
|
|
| Can PRS for melanoma be used for population screening? |
|
|
| 13:30 | 1C: My Profiled Genome (pre-registered session) More info here! |
| |
|
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| R: room 82 Chair: Johan den Dunnen (NVHG) |
| |
| 15:00 | Parallel session 2 A/B |
| ||
|
| 15:00 | Parallel session 2A |
| |
|
|
| R: Auditorium Chair: Gijs Santen (NVHG) |
| |
|
|
| 15:00 | Marieke Klein (Nijmegen) |
|
|
|
|
| Interactions of rare copy number variations with polygenic risk scores in psychiatric disorders and quantitative traits |
|
|
|
| 15:20 | Janita Bralten (Nijmegen) |
|
|
|
|
| Shared underlying genetic architecture of psychiatric symptoms with hematological traits |
|
|
|
| 15:40 | Eline van der Sluijs (Leiden) |
|
|
|
|
| Effect of clonazepam in patients with ARID1B-related intellectual disability |
|
|
|
| 16:00 | Lex Dingemans (Nijmegen) |
|
|
|
|
| PhenomAD-NDD: the Phenomics Aggregation Database of comorbidities in 42,411 pediatric individuals with Neuro Development Disorders |
|
|
| 15:00 | Parallel session 2B |
| |
|
|
| R: Parkzaal Chair: Roland Kuiper (NVHG) |
| |
|
|
| 15:00 | Naijm Lahrouchi (Amsterdam) |
|
|
|
|
| Loss-of function variance POPDC2 cause a novel autosomal recessive syndrome with sinus node disease and AV conduction defects in combination with hypertrophic cardiomyopathy |
|
|
|
| 15:20 | Gaby Schobers (Nijmegen) |
|
|
|
|
| Finally finding the second variant in recessive disorders by genome sequencing |
|
|
|
| 15:40 | Maayke de Koning (Leiden) |
|
|
|
|
| Biallellic variants in SNAPIN are associated with a novel foetal neuroanatomical phenotype |
|
|
|
| 16:00 | Robin Wijngaard (Nijmegen) |
|
|
|
|
| Analysis of mobile elements in + 60,000 exome sequencing samples identifies pathogenic variants in 3 per 10,000 patients |
|
| 16:20 | Posters presentation with coffee & tea: Holland Foyer & Room 65 |
| ||
| 17:30 | Keynote lecture by Dr. Benjamin Peter (Leipzig) |
| ||
|
| The Neanderthal family project |
| ||
|
| R: Auditorium Chair: Roland Kuiper (NVHG) |
| ||
| 18:30 | Social evening program: Brabantzaal |
| ||
| 18:30 | Pre-dinner drinks |
|
| |
| 19:00 | Dinner |
|
|
|
| 21:00 | Network event |
|
| |
|
|
|
|
|
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| Time | Friday 21st April |
| ||
| 08:30 | Registration |
|
| |
|
| R: Holland Foyer |
|
| |
| 09:00 | Plenary session 3: HUGE NL |
| ||
|
| Chair: Johan den Dunnen, Lude Franke, Mieke van Haelst & Terry Vrijenhoek (NVHG) |
| ||
|
| HUGE NL is gradually developing as the national think tank for Human Genetics in the Netherlands. Creator Terry Vrijenhoek lays out why we want this platform (yes, you too), what has happened thus far, and what grant, publication, and expansion opportunities are at the horizon. Spoiler alert: some of the ‘profiled’ (from the My Profiled Genome session on Day 1) may have their coming-out! |
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| 10:10 | Coffee break: Holland Foyer |
| ||
| 10:30 | Parallel sessions 3: A/B |
| ||
|
| 10:30 | Parallel session 3A |
| |
|
|
| R: Auditorium Chair: Lisenka Vissers (NVHG) |
| |
|
|
| 10:30 | Dilys Weijers (Utrecht) |
|
|
|
|
| Molecular analysis of cancer genomes in children with Lynch syndrome: exploring causal associations |
|
|
|
| 10:50 | Snežana Hinić (Nijmegen) |
|
|
|
|
| Biallelic germline pathogenic variants in CHEK2 predispose to multiple primary malignancies in the absence of homologous recombination deficiency |
|
|
|
| 11:10 | Lore van Riel (Amsterdam) |
|
|
|
|
| Prevalence of pathogenic FLCN variants |
|
|
|
| 11:30 | Richarda de Voer (Nijmegen) |
|
|
|
|
| Microsatellite instability in non-colorectal and non-endometrial malignancies in patients with Lynch syndrome |
|
|
| 10:30 | Parallel session 3B |
| |
|
|
| Chair: Lude Franke (NVHG) |
| |
|
|
| 10:30 | Marlen Lauffer (Leiden) |
|
|
|
|
| Patient and variant stratification for personalized genetic treatments of nano‐rare diseases |
|
|
|
| 10:50 | Rick Essers (Maastricht) |
|
|
|
|
| The nature and prevalence of chromosomal dynamics in first trimester spontaneous pregnancy loss |
|
|
|
| 11:10 | Wouter Steyaert (Nijmegen) |
|
|
|
|
| Systematic Pan-European reanalysis of 6,004 genetically undiagnosed rare disease families yields 506 new diagnoses |
|
|
|
| 11:30 | Peter Taschner (Leiden) |
|
|
|
|
| Check the test: how to assess the quality of Direct‐to‐Consumer genetic tests? |
|
| 12:00 Lunch and poster viewing: Holland Foyer & room 65 |
| |||
| 12:30 | NVHG General Assembly |
| ||
|
| Room: Auditorium |
|
| |
| 13:15 Plenary session 4: Innovations in Genomics |
| |||
|
| R: Auditorium Chairs: Lisenka Vissers (NVHG) & Masoud Zamani Esteki (Maastricht) |
| ||
|
| Dr. Alexander Hoischen (Nijmegen) |
| ||
|
| Optical genome mapping: Hidden SVs in rare diseases |
| ||
|
| Dr. Ir. Jeroen de Ridder (Utrecht) |
| ||
|
| Ultra-fast deep-learned pediatric CNS tumor classification during surgery |
| ||
|
| Prof. Dr. Bas Heijmans (Leiden) |
| ||
|
| Genetics: a gateway to understanding epigenetics |
| ||
| 15:10 | Emotional genetics: Auditorium |
| ||
| 15:30 NVHG award ceremony |
| |||
|
| R: Auditorium Chair: Mieke van Haelst (NVHG) |
| ||
|
| Lodewijk Sandkuijl Award lecture 2023 |
| ||
|
| NVHG Young Investigator Award, Annual Award, Poster Award |
| ||
| 16:15 Closing remarks |
|
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SPONSORS
We express our gratitude to all our sponsors for their continued support.
YOUNG INVESTIGATOR AWARD
The Young Investigator Award will be awarded to a promising young, talented, early-career scientist, who defended his/her dissertation between 01 of April 2022 and 01 April 2023.
Registration deadline is 1 of April
ANNUAL AND POSTER AWARDS
For outstanding spoken and poster contributions at the NVHG Annual Meeting
Submission deadline is 21 of March
REGISTRATION
When registering for the conference, you will have to agree to the General Terms & Conditions for participants.
NVHG collects and uses your personal information to:
– facilitate registration for the event
– send you a confirmation e-mail
– send you a survey after the event
Non-Members
-
This price includes Thursday and Friday
-
You can also book only one day:
Only Thursday €300
Only Friday €275
NVHG Members
-
This price includes Thursday and Friday
-
You can also book only one day:
Only Thursday €225
Only Friday €200
IMPORTANT:
Please note that accommodation needs to booked by the participants themselves.
A link to book at NH hotel Veldhoven is available HERE.
More information about the hotel here below.
GENERAL INFORMATION
VENUE
NH Eindhoven Conference Centre Koningshof in Veldhoven
Book your stay!
Rates April 20, 2023
Standard single room
including breakfast and tourist tax € 128.70 per room
Standard double room
including breakfast and tourist tax € 134.40 per room
*The rate for the tourist tax 2023 is set at € 2.70 per person per night.
CANCELLATIONS AND REFUNDS
Notice of cancellation must be made in writing by e-mail to the Meeting organisers: henny.schurmann@mumc.nl
Registration fees may be refunded if written cancellation has been received as follows:
- until 31 of March, 2023: full refund
- from 1 of April, 2023: 50% refund
The cancellation will not be effective until a written acknowledgement from the NVHG organisers is received. In the case of over-payment or double payment, refund requests must be made in writing and sent to the meeting organisers by e-mail. No refunds will be granted for unattended events or early termination of attendance, in case of cancellation of speakers or any other incidents during the conference, which are beyond the control of the conference organisers.
No exceptions to the refund policy can be made, including health or family issues. By registering to the NVHG Annual Meeting 2023, participants agree that the organising committee does not assume any liability whatsoever.
CERTIFICATES
Certificates of attendance will be sent to all participants electronically after the meeting when attendance is confirmed in the online platform.
ACCREDITATION
Accreditation will be given only when participants request it at the registration and when the attendance is confirmed.
BIG number and full name should be provided at registration.
LANGUAGE
The official language of the meeting will be English. No simultaneous translation will be provided.
