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ABOUT THE MEETING

We are pleased to announce the BeSHG/NVHG annual genetics symposium, to be held on 21st and 22nd April 2022 at the Bruges Meeting & Convention Centre (BMCC).

This 2-day symposium will be preceded on 20th April 2022 by the Genetics Retreat (previously known as the Rolduc meeting).

The 2022 genetics symposium will be organized jointly by the Belgian Society for Human Genetics (BeSHG) and the Dutch Society for Human Genetics (NVHG). We hereby continue a tradition we started in 2016 to have a joint meeting every 3 years. As usual, the NVHG symposium is organized in collaboration with the VKGL, VKGN and NACGG.

Please note that neither BeSHG nor NVHG nor Genetics Retreat will organize a separate meeting in 2022.

Theme
The theme of the meeting will be ‘New advances and tools towards personalized medicine of genetic disorders’. A field of medical genetics that is evolving fast with emerging genomic technologies.

Young researchers
Together with the organizing committee of the Genetics Retreat, we call upon young researchers (PhD students) to attend both meetings.

Venue
BMCC is a brand new, modern convention center (opening January 2022) in the heart of historic Bruges, which offers a unique experience.

Staying overnight in Bruges
Looking for an inexpensive hotel to stay overnight? Please check our suggestions. Do not wait too long to book a room. Bruges is a very popular city.

Abstracts
Abstracts should be submitted before 15 February 2022 through the BeSHG-website following the published guidelines.

Follow the BeSHG website for the most actual information on the symposium. The final program of the meeting will become available towards the end of March.

We hope to meet you all at the 2022 BeSHG and NVHG symposium and Genetics Retreat in April in Bruges. Feel free to forward this mailing to your colleagues.

On behalf of the Executive Committees,
Dr. Arvid Suls (Local organizer)
Prof. dr. Gert Matthijs (President BeSHG)
Dr. Mieke van Haelst (President NVHG)
Dr. Willem Voncken and dr. Alex Hoischen on behalf of the organizing committee of the Genetics Retreat

Local organizing team
UZA/UA Centre of Medical Genetics Antwerp
E: arvid.suls@uantwerpen.be
T: +32 (0) 3 275 9763

ABOUT THE MEETING

NVHG Annual Meeting 2023

As every year, the NVHG organizes a conference for all Dutch geneticists to connect, share knowledge, collaborate, and network. The NVHG aims to provide the latest genetics and genomics advancements, from basic to translational research from within and outside of the Netherlands.

The 2023 NVHG Annual Meeting took place on 20th and 21st of April 2023 in Koningshof, Veldhoven. The word cloud that was created by the participants provides an impression of that meeting.

WELCOME

Dear colleagues,

Welcome to the annual meeting of the Dutch society of Human Genetics. It is a pleasure to welcome you in again Veldhoven. For the first time in three years’ time a “live-only” meeting. Back to the old pre-COVID times!

The NVHG organizes this unique yearly conference for all Dutch geneticists to connect, share knowledge, collaborate, and network. We aim to provide the latest genetics and genomics advancements, from basic to translational research.

This years’ scientific program will focus on diversity in genetics, therapy development, newborn- and population screenings options and technological developments. These topics will be addressed during presentations and panel discussions throughout the conference.

We have invited plenary speakers Charles Agyemang, Bart Ferwerda and Veronika Lipphardt, who will share their knowledge and experiences in studying Diversity in Genetics. Our keynote speaker Dr. Benjamin Peter will give us some insight in the world of archeogenetics with a presentation on The Neanderthal family project.

The second day will start with HUGE nl, a national platform for all stakeholders in genetics, to jointly discuss and formulate how to best approach and apply the newest genetic knowledge and possibilities in society.

We have invited excellent plenary speakers to enlighten us with recent innovations in genomics; Alexander Hoischen, Jeroen de Ridder, Bas Heijmans and Jesse Swen, will provide an update on optical genome mapping, nanopore sequencing, epigenetic profiling and “genetics informed drug treatment”.

Finally, we are proud to announce that Prof. dr. Christian Gilissen, has been selected as the recipient of the NVHG ‘Lodewijk Sandkuijl Lecture 2023’.

This meeting would not have been possible without the generous support from our sponsors, the Simons Fonds as well as bioscience companies. We thank all of them and encourage all participants to see the representatives at the stands to take note of the products offered by them.

I wish you an inspiring meeting and a great time interacting with your colleagues on stage and/or on the dancefloor!
Mieke van Haelst
President

LODEWIJK SANDKUIJL

DR. MICHEL NIVARD

The winner of the Lodewijk Sandkuijl award 2021 is Dr. Michel Nivard, VU University Amsterdam. He will receive this prize during the NVHG Annual Meeting on Friday 17 September, and will give an overview of the research he is conducting. Interested? Register now for the NVHG Annual Meeting 2021.

GALJAARD LECTURE

PROF. CISCA WIJMENGA

The NVHG board is proud to announce that the biannual Galjaard lifetime achievement award 2022 is awarded to prof. dr. Cisca Wijmenga for her international leadership in the field of human genetics.  Prof. dr. Wijmenga will give her award lecture at the BeSHG/NVHG joint symposium on 21 April in Bruges, Belgium.

SPEAKERS

PROGRAM

*This is preliminary program (version 16 of April 2023)

Time

Thursday 20th April

09:00

Registration

 

R: Holland Foyer

09:45

Opening by Prof. Dr. Mieke van Haelst (President NVHG)

 

R: Auditorium

10:00

Plenary session 1

 

R: Auditorium Chairs: André Uitterlinden & Gijs Santen (NVHG)

10:00

Prof. Dr. Charles Agyemang (Amsterdam)

 

Ethnic inequalities in health in Europe: Current & Future perspectives

10:30

Dr. Bart Ferwerda (Amsterdam)

 

HELIUS – a genetic map of a modern urban society

11:00

Prof. Dr. Veronika Lipphardt (Freiburg)

 

Genetic research in underrepresented population

11:30

Prof. Dr. Mieke van Haelst (NVHG)

 

Clinical genetic experiences in a Caribbean setting

12:00

Plenary session 2

 

R: Auditorium Chair: Lude Franke (NVHG)

12:00

Prof. Dr. Jesse Swen (Leiden)

 

Genetics informed drug treatment: from promise to practice

12:30

Lunch: Holland Foyer & room 65

  

13:30

Parallel session 1 A/B/C Co-organized with VKGL, VKGN, NACGG

13:30

1A: Diversity in Genetic Studies – a debate

 

R: Auditorium Chairs: Boy Vijlbrief (Rotterdam) & Sam Riedijk (Rotterdam)

13:30

1B: Lifelong Screening

 

R: Parkzaal Chairs Erik Sistermans (Amsterdam) & Marielle van Gijn (Groningen)

13:30

Sander Stegmann (Maastricht)

 

Use of WES analysis for preconceptional screening, the Maastricht experience

13:50

Jasper Linthorst (Amsterdam)

 

Improving prenatal screening by NIPT datamining

14:10

Gea Kiewiet PhD (Groningen)

 

Towards NGS-based newborn screening: a study to prepare for challenges ahead

14:30

Nienke van der Stoep (Leiden)

 

Can PRS for melanoma be used for population screening?

13:30

1C: My Profiled Genome (pre-registered session)

   

R: room 82 Chair: Johan den Dunnen (NVHG)

15:00

Parallel session 2 A/B

15:00

Parallel session 2A

 

R: Auditorium Chair: Gijs Santen (NVHG)

15:00

Marieke Klein (Nijmegen)

 

Interactions of rare copy number variations with polygenic risk scores in psychiatric disorders and quantitative traits

15:20

Janita Bralten (Nijmegen)

 

Shared underlying genetic architecture of psychiatric symptoms with hematological traits

15:40

Eline van der Sluijs (Leiden)

 

Effect of clonazepam in patients with ARID1B-related intellectual disability

16:00

Lex Dingemans (Nijmegen)

 

PhenomAD-NDD: the Phenomics Aggregation Database of comorbidities in 42,411 pediatric individuals with Neuro Development Disorders

15:00

Parallel session 2B

 

R: Parkzaal Chair: Roland Kuiper (NVHG)

15:00

Naijm Lahrouchi (Amsterdam)

 

Loss-of function variance POPDC2 cause a novel autosomal recessive syndrome with sinus node disease and AV conduction defects in combination with hypertrophic cardiomyopathy

15:20

Gaby Schobers (Nijmegen)

 

Finally finding the second variant in recessive disorders by genome sequencing

15:40

Maayke de Koning (Leiden)

 

Biallellic variants in SNAPIN are associated with a novel foetal neuroanatomical phenotype

16:00

Robin Wijngaard (Nijmegen)

 

Analysis of mobile elements in + 60,000 exome sequencing samples identifies pathogenic variants in 3 per 10,000 patients

16:20

Posters presentation with coffee & tea: Holland Foyer & Room 65

17:30

Keynote lecture by Dr. Benjamin Peter (Leipzig)

 

The Neanderthal family project

 

R: Auditorium Chair: Roland Kuiper (NVHG)

18:30

Social evening program: Brabantzaal

18:30

Pre-dinner drinks

19:00

Dinner

21:00

Network event

  

Time

Friday 21st April

08:30

Registration

 

R: Holland Foyer

09:00

Plenary session 3: HUGE NL

 

Chair: Johan den Dunnen, Lude Franke, Mieke van Haelst & Terry Vrijenhoek (NVHG)

 

The national think tank for Human Genetics in the Netherlands

10:10

Coffee break: Holland Foyer

10:30

Parallel sessions 3: A/B

10:30

Parallel session 3A

 

R: Auditorium Chair: Lisenka Vissers (NVHG)

10:30

 Dilys Weijers (Utrecht)

 

Molecular analysis of cancer genomes in children with Lynch syndrome: exploring causal associations

10:50

 Snežana Hinić (Nijmegen)

 

Biallelic germline pathogenic variants in CHEK2 predispose to multiple primary malignancies in the absence of homologous recombination deficiency

11:10

 Lore van Riel (Amsterdam)

 

Prevalence of pathogenic FLCN variants

11:30

 Richarda de Voer (Nijmegen)

 

Microsatellite instability in non-colorectal and non-endometrial malignancies in patients with Lynch syndrome

10:30

Parallel session 3B

 

Chair: Lude Franke (NVHG)

10:30

 Marlen Lauffer (Leiden)

 

Patient and variant stratification for personalized genetic treatments of nano‐rare diseases

10:50

 Rick Essers (Maastricht)

 

The nature and prevalence of chromosomal dynamics in first trimester spontaneous pregnancy loss

11:10

 Wouter Steyaert (Nijmegen)

 

Systematic Pan-European reanalysis of 6,004 genetically undiagnosed rare disease families yields 506 new diagnoses

11:30

 Peter Taschner (Leiden)

 

Check the test: how to assess the quality of Direct‐to‐Consumer genetic tests?

12:00

Lunch and poster viewing: Holland Foyer & room 65

12:30

NVHG General Assembly

 

Room: Auditorium

13:15

Plenary session 4: Innovations in Genomics

 

R: Auditorium Chairs: Lisenka Vissers (NVHG) & Masoud Zamani Esteki (Maastricht)

 

Dr. Alexander Hoischen (Nijmegen)

 

Optical genome mapping: Hidden SVs in rare diseases

 

Dr. Ir. Jeroen de Ridder (Utrecht)

 

Ultra-fast deep-learned pediatric CNS tumor classification during surgery

 

Prof. Dr. Bas Heijmans (Leiden)

 

Genetics: a gateway to understanding epigenetics

15:10

Emotional genetics: Auditorium

15:30

NVHG award ceremony

 

R: Auditorium Chair: Mieke van Haelst (NVHG)

 

Lodewijk Sandkuijl Award lecture 2023

 

NVHG Young Investigator Award, Annual Award, Poster Award

16:15

Closing remarks

 

 

 

 

 

 

 

Time

Thursday 20th April

 

 

09:00

Registration

 

 

 

 

R: Holland Foyer

 

 

 

09:45

Opening by Prof. Dr. Mieke van Haelst (President NVHG)

 

 

 

R: Auditorium

 

 

 

10:00

Plenary session 1

 

 

 

 

R: Auditorium Chairs: André Uitterlinden & Gijs Santen (NVHG)

 

 

 

10:00

Prof. Dr. Charles Agyemang (Amsterdam)

 

 

 

 

Ethnic inequalities in health in Europe: Current & Future perspectives

 

 

 

10:30

Dr. Bart Ferwerda (Amsterdam)

 

 

 

 

HELIUS – a genetic map of a modern urban society

 

 

 

11:00

Prof. Dr. Veronika Lipphardt (Freiburg)

 

 

 

 

Genetic research in underrepresented population

 

 

 

11:30

Prof. Dr. Mieke van Haelst (NVHG)

 

 

 

 

Clinical genetic experiences in a Caribbean setting

 

 

12:00

Plenary session 2

 

 

 

 

R: Auditorium Chair: Lude Franke (NVHG)

 

 

 

12:00

Prof. Dr. Jesse Swen (Leiden)

 

 

 

 

Genetics informed drug treatment: from promise to practice

 

 

12:30

Lunch: Holland Foyer & room 65

 

 

 

 

 

 

 

 

13:30

Parallel session 1 A/B/C Co-organized with VKGL, VKGN, NACGG

 

 

 

13:30

1A: Diversity in Genetic Studies – a debate

 

 

 

 

R: Auditorium Chairs: Boy Vijlbrief (Rotterdam) & Sam Riedijk (Rotterdam)

 

 

 

13:30

1B: Lifelong Screening

 

 

 

 

R: Parkzaal Chairs Erik Sistermans (Amsterdam) & Marielle van Gijn (Groningen)

 

 

 

 

13:30

Sander Stegmann (Maastricht)

 

 

 

 

 

Use of WES analysis for preconceptional screening, the Maastricht experience

 

 

 

 

13:50

Jasper Linthorst (Amsterdam)

 

 

 

 

 

Improving prenatal screening by NIPT datamining

 

 

 

 

14:10

Gea Kiewiet PhD (Groningen)

 

 

 

 

 

Towards NGS-based newborn screening: a study to prepare for challenges ahead

 

 

 

 

14:30

Nienke van der Stoep (Leiden)

 

 

 

 

 

Can PRS for melanoma be used for population screening?

 

 

 

13:30

1C: My Profiled Genome (pre-registered session) More info here!

 

 

   

 

R: room 82 Chair: Johan den Dunnen (NVHG)

 

 

15:00

Parallel session 2 A/B

 

 

 

15:00

Parallel session 2A

 

 

 

 

R: Auditorium Chair: Gijs Santen (NVHG)

 

 

 

 

15:00

Marieke Klein (Nijmegen)

 

 

 

 

 

Interactions of rare copy number variations with polygenic risk scores in psychiatric disorders and quantitative traits

 

 

 

 

15:20

Janita Bralten (Nijmegen)

 

 

 

 

 

Shared underlying genetic architecture of psychiatric symptoms with hematological traits

 

 

 

 

15:40

Eline van der Sluijs (Leiden)

 

 

 

 

 

Effect of clonazepam in patients with ARID1B-related intellectual disability

 

 

 

 

16:00

Lex Dingemans (Nijmegen)

 

 

 

 

 

PhenomAD-NDD: the Phenomics Aggregation Database of comorbidities in 42,411 pediatric individuals with Neuro Development Disorders

 

 

 

15:00

Parallel session 2B

 

 

 

 

R: Parkzaal Chair: Roland Kuiper (NVHG)

 

 

 

 

15:00

Naijm Lahrouchi (Amsterdam)

 

 

 

 

 

Loss-of function variance POPDC2 cause a novel autosomal recessive syndrome with sinus node disease and AV conduction defects in combination with hypertrophic cardiomyopathy

 

 

 

 

15:20

Gaby Schobers (Nijmegen)

 

 

 

 

 

Finally finding the second variant in recessive disorders by genome sequencing

 

 

 

 

15:40

Maayke de Koning (Leiden)

 

 

 

 

 

Biallellic variants in SNAPIN are associated with a novel foetal neuroanatomical phenotype

 

 

 

 

16:00

Robin Wijngaard (Nijmegen)

 

 

 

 

 

Analysis of mobile elements in + 60,000 exome sequencing samples identifies pathogenic variants in 3 per 10,000 patients

 

 

16:20

Posters presentation with coffee & tea: Holland Foyer & Room 65

 

 

17:30

Keynote lecture by Dr. Benjamin Peter (Leipzig)

 

 

 

The Neanderthal family project

 

 

 

R: Auditorium Chair: Roland Kuiper (NVHG)

 

 

18:30

Social evening program: Brabantzaal

 

 

18:30

Pre-dinner drinks

 

 

 

19:00

Dinner

 

 

 

 

21:00

Network event

 

 

 

 

 

 

 

 

 

Time

Friday 21st April

 

 

08:30

Registration

 

 

 

 

R: Holland Foyer

 

 

 

09:00

Plenary session 3: HUGE NL

 

 

 

Chair: Johan den Dunnen, Lude Franke, Mieke van Haelst & Terry Vrijenhoek (NVHG)

 

 

 

HUGE NL is gradually developing as the national think tank for Human Genetics in the Netherlands. Creator Terry Vrijenhoek lays out why we want this platform (yes, you too), what has happened thus far, and what grant, publication, and expansion opportunities are at the horizon. Spoiler alert: some of the ‘profiled’ (from the My Profiled Genome session on Day 1) may have their coming-out!

 

 

10:10

Coffee break: Holland Foyer

 

 

10:30

Parallel sessions 3: A/B

 

 

 

10:30

Parallel session 3A

 

 

 

 

R: Auditorium Chair: Lisenka Vissers (NVHG)

 

 

 

 

10:30

 Dilys Weijers (Utrecht)

 

 

 

 

 

Molecular analysis of cancer genomes in children with Lynch syndrome: exploring causal associations

 

 

 

 

10:50

 Snežana Hinić (Nijmegen)

 

 

 

 

 

Biallelic germline pathogenic variants in CHEK2 predispose to multiple primary malignancies in the absence of homologous recombination deficiency

 

 

 

 

11:10

 Lore van Riel (Amsterdam)

 

 

 

 

 

Prevalence of pathogenic FLCN variants

 

 

 

 

11:30

 Richarda de Voer (Nijmegen)

 

 

 

 

 

Microsatellite instability in non-colorectal and non-endometrial malignancies in patients with Lynch syndrome

 

 

 

10:30

Parallel session 3B

 

 

 

 

Chair: Lude Franke (NVHG)

 

 

 

 

10:30

 Marlen Lauffer (Leiden)

 

 

 

 

 

Patient and variant stratification for personalized genetic treatments of nano‐rare diseases

 

 

 

 

10:50

 Rick Essers (Maastricht)

 

 

 

 

 

The nature and prevalence of chromosomal dynamics in first trimester spontaneous pregnancy loss

 

 

 

 

11:10

 Wouter Steyaert (Nijmegen)

 

 

 

 

 

Systematic Pan-European reanalysis of 6,004 genetically undiagnosed rare disease families yields 506 new diagnoses

 

 

 

 

11:30

 Peter Taschner (Leiden)

 

 

 

 

 

Check the test: how to assess the quality of Direct‐to‐Consumer genetic tests?

 

 

12:00 Lunch and poster viewing: Holland Foyer & room 65

 

 

12:30

NVHG General Assembly

 

 

 

Room: Auditorium

 

 

 

13:15 Plenary session 4: Innovations in Genomics

 

 

 

R: Auditorium Chairs: Lisenka Vissers (NVHG) & Masoud Zamani Esteki (Maastricht)

 

 

 

Dr. Alexander Hoischen (Nijmegen)

 

 

 

Optical genome mapping: Hidden SVs in rare diseases

 

 

 

Dr. Ir. Jeroen de Ridder (Utrecht)

 

 

 

Ultra-fast deep-learned pediatric CNS tumor classification during surgery

 

 

 

Prof. Dr. Bas Heijmans (Leiden)

 

 

 

Genetics: a gateway to understanding epigenetics

 

 

15:10

Emotional genetics: Auditorium

 

 

15:30 NVHG award ceremony

 

 

 

R: Auditorium Chair: Mieke van Haelst (NVHG)

 

 

 

Lodewijk Sandkuijl Award lecture 2023

 

 

 

NVHG Young Investigator Award, Annual Award, Poster Award

 

 

16:15 Closing remarks

 

 

 

 

 

 

 

 

SPONSORS

We express our gratitude to all our sponsors for their continued support.

YOUNG INVESTIGATOR AWARD

YIA NOMINATIONS
Register

The Young Investigator Award will be awarded to a promising young, talented, early-career scientist, who defended his/her dissertation between 01 of April 2022 and 01 April 2023. 

Registration deadline is 1 of April

ANNUAL AND POSTER AWARDS

ABSTRACT SUBMISSIONS
Submit an abstract

For outstanding spoken and poster contributions at the NVHG Annual Meeting

Submission deadline is 21 of March

REGISTRATION

When registering for the conference, you will have to agree to the General Terms & Conditions for participants.
NVHG collects and uses your personal information to:
–          facilitate registration for the event
–          send you a confirmation e-mail
–          send you a survey after the event

Non-Members

350
  • This price includes Thursday and Friday
  • You can also book only one day:
    Only Thursday €‎300
    Only Friday €‎275

NVHG Members

275
  • This price includes Thursday and Friday
  • You can also book only one day:
    Only Thursday €‎225
    Only Friday €‎200

IMPORTANT:

Please note that accommodation needs to booked by the participants themselves.
A link to book at NH hotel Veldhoven is available HERE.

More information about the hotel here below.

GENERAL INFORMATION

VENUE

NH Eindhoven Conference Centre Koningshof in Veldhoven

Book your stay!

You can now book your stay during the NVHG Annual Meeting 2023 directly at the hotel website using this link:
Click Here

Rates April 20, 2023

Standard single room 
including breakfast and tourist tax € 128.70 per room

Standard double room
including breakfast and tourist tax € 134.40 per room

*The rate for the tourist tax 2023 is set at € 2.70 per person per night.

CANCELLATIONS AND REFUNDS

Notice of cancellation must be made in writing by e-mail to the Meeting organisers:  henny.schurmann@mumc.nl

Registration fees may be refunded if written cancellation has been received as follows:

  • until 31 of March, 2023: full refund
  • from 1 of April, 2023: 50% refund

The cancellation will not be effective until a written acknowledgement from the NVHG organisers is received. In the case of over-payment or double payment, refund requests must be made in writing and sent to the meeting organisers by e-mail. No refunds will be granted for unattended events or early termination of attendance, in case of cancellation of speakers or any other incidents during the conference, which are beyond the control of the conference organisers.

No exceptions to the refund policy can be made, including health or family issues. By registering to the NVHG Annual Meeting 2023, participants agree that the organising committee does not assume any liability whatsoever.

 

CERTIFICATES

Certificates of attendance will be sent to all participants electronically after the meeting when attendance is confirmed in the online platform.

ACCREDITATION

Accreditation will be given only when participants request it at the registration and when the attendance is confirmed.
BIG number and full name should be provided at registration.

LANGUAGE

The official language of the meeting will be English. No simultaneous translation will be provided.

My Profiled Genome

So far, the focus of DNA analysis has been mainly in the field of diagnostics, i.e. finding a
link between DNA variants and disease. However, the same technology can also be
applied prospectively, analysing a healthy individual’s genome. When a healthy individual
is interested in the information the genome contains, she/he has nowhere to go: Dutch
centers performing clinical DNA diagnostics not equipped to analyse a healthy individual’s
genome, and when turning to commercial parties, experts express concerns regarding
validity of results and privacy.

In this session, we want to gather healthy individuals who somehow analysed their own
genome, using array technology, and/or whole exome/genome sequencing. The sessions
starts with an introduction by Johan den Dunnen, sharing the experiences he gained
trying to get his genome sequenced and analysed, as well as the information it contained.
Next, we hope others are willing to share some of their experiences. Finally, we want to
discuss what needs to be done to make DNA analysis for healthy individuals possible.
Topics to discuss include who could/should do it, how will people get the result, and do
we teach children enough so they can understand the result and its consequences?

If you have analyzed your genome, and wish to contribute to this session, please register
with Johan den Dunnen (ddunnen@humgen.nl).