Most metabolic conditions and many other genetic diseases follow an autosomal recessive inheritance pattern. When a child is diagnosed with a severe genetic condition, parents often ask ‘could we have known before that both of us are carrier of this condition’? In theory the answer is yes, but in practice screening for carrier status before pregnancy is not available to most parents-to-be. In this webinar we will discuss a large pilot preconception carrier screening program that took place in Australia, as well as a recent Dutch Health Council report. We will discuss potential next steps.